Peer-reviewed papers | Patents | Conference abstracts

  1. Tong, X.; Yang, F., Recent Progress in Developing Injectable Matrices for Enhancing Cell Delivery and Tissue Regeneration. Adv. Healthc. Mater., 2017, [DOI: 10.1002/adhm.201701065] [PMID: 29280328]
  2. Tong, X.; Yang, F., Sliding Hydrogels with Mobile Molecular Ligands and Crosslinks as 3D Stem Cell Niche. Adv. Mater., 2016, 28 (33), 7257-63. [PMID: 27305637][PMC5127628]
  3. Tong, X.; Jiang, J.; Zhu, D.; Yang, F., Hydrogels with Dual Gradients of Mechanical and Biochemical Cues for Deciphering Cell-Niche Interactions, ACS Biomater. Sci. Eng., 2016, 2, 845-852. [view]
  4. Tong, X.; Lee, S.; Bararpour, L.; Yang, F., Sustained protein release from hydrogels by tuning poly(ethylene glycol) structure and degradation, Macromol. Biosci., 2015, 15, 1679–1686.[PMID: 26259711][PMC5127624]
  5. Tong, X.; Yang, F., Interpenetrating network hydrogel as biomimetic cell niche with independently tunable biochemical and mechanical properties, Biomaterials, 2014, 35, 1807-1815.[PMID: 24331710]
  6. Tong, X.; Lai, J.; Guo, B.; Huang, Y., A new end group structure of PEG for hydrolysis- resistant biomaterials. J. Polym. Sci., Part A: Polym. Chem., 2011, 49, 1513-1516.[view]
  7. Tong, X.; Guo, B.; Huang, Y., Toward the synthesis of sequence-controlled vinyl copolymers. Chem. Comm., 2011, 47, 1455-1457.[PMID: 21125120]
  8. Tong, X.; Gao, P.; Zhang, X.; Ye, L.; Zhang, A.; Feng, Z., End-capping double-chain stranded polypseudorotaxanes using lengthily tunable poly(2-hydroxyethyl methacrylate) blocks via atom transfer radical polymerization. Polym. Int., 2010, 59, 917-922.[view]
  9. Tong, X.; Zhang, X.; Ye, L.; Zhang, A.; Feng, Z., Synthesis and characterization of block copolymers comprising a polyrotaxane middle block flanked by two brush-like PCL blocks. Soft Matter, 2009, 5, 1848-1855.[view]
  10. Tong, X.; Zhang, X.; Ye, L.; Zhang, A.; Feng, Z., Novel main-chain polyrotaxanes synthesized via ATRP of HEMA initiated with polypseudorotaxanes comprising BriB-PEG-iBBr and alpha-CDs. Polymer, 2008, 49, 4489-4493.[view]
  11. Tong, X.; Hou, D.; Zhang, X.; Ye, L.; Zhang, A.; Feng, Z., Synthesis and characterization of polyrotaxanes made from alpha-CDs threaded onto triblock copolymers with PEG as a central axle and flanked by two low molecular weight polystyrenes as outer stoppers. Chinese J. Poly. Sci., 2008, 26, 723-732. [view]
  12. Yan, X.; Yang, X.; Tong, X. *; Huang Y.*, A method to accelerate the gelation of disulfide-crosslinked hydrogels, Chinese J. Poly. Sci., 2015, 33, 118-127. [view]
  13. Song, Q., Luo, Z.; Tong, X. *; Du, Y.; Huang, Y., Glutathione as the end capper for cryclodextrin/PEG polyrotaxanes, Chinese J. Poly. Sci., 2014, 32, 1003-1009. [view]

  14. Zhu, D.; Tong, X..; Trinh, P.; Yang, F., Mimicking Cartilage Tissue Zonal Organization by Engineering Tissue-scale Gradient Hydrogels as 3D Cell Niche. Tissue engineering. Part A 2017, (DOI 10.1089/ten.TEA.2016.0453. [PMID: 28385124]
  15. Lee, S.; Serpooshan, V.; Tong, X.; Venkatraman, S.; Lee, M.; Lee, J.; Chirikian, O.; Wu, J. C.; Wu, S. M.; Yang, F., Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness. Biomaterials 2017, 131, 111-120.[view][PMID 28384492] [PMC5558787]
  16. Tevlin, R.; Seo, E. Y.; Marecic, O.; McArdle, A.; Tong, X.; Zimdahl, B.; Malkovskiy, A.; Sinha, R.; Gulati, G.; Li, X.; Wearda, T.; Morganti, R.; Lopez, M.; Ransom, R. C.; Duldulao, C. R.; Rodrigues, M.; Nguyen, A.; Januszyk, M.; Maan, Z.; Paik, K.; Yapa, K.-S.; Rajadas, J.; Wan, D. C.; Gurtner, G. C.; Snyder, M.; Beachy, P. A.; Yang, F.; Goodman, S. B.; Weissman, I. L.; Chan, C. K. F.; Longaker, M. T., Pharmacological rescue of diabetic skeletal stem cell niches. Science Translational Medicine 2017, 9 (372). [PMID 28077677] [PMC5725192]
  17. Daldrup-Link, H. E.; Chan, C.; Lenkov, O.; Taghavigarmestani, S.; Nazekati, T.; Nejadnik, H.; Chapelin, F.; Khurana, A.; Tong, X.; Yang, F.; Pisani, L.; Longaker, M.; Gambhir, S. S., Detection of Stem Cell Transplant Rejection with Ferumoxytol MR Imaging: Correlation of MR Imaging Findings with Those at Intravital Microscopy. Radiology 2017, 161-139. [PMID 28128708] [PMC5548449]
  18. Wang, T.; Lai, J. H.; Han, L.-H.; Tong, X.; Yang, F., Modulating stem cell-chondrocyte interactions for cartilage repair using combinatorial extracellular matrix-containing hydrogels. J. Mater. Chem. B, 2016, 4 (47), 7641-7650. [view]
  19. Wang, C.; Tong, X.; Jiang, X.; Yang, F., Effect of Matrix Metalloproteinase-Mediated Matrix Degradation on Glioblastoma Cell Behavior in 3D PEG-based Hydrogels. J. Biomed. Mater. Res. Part A, 2016, 105 (3), 770-778. [PMID 27770562] [PMC5276739]
  20. Lee, S.; Tong, X.; Yang, F., Effects of the poly(ethylene glycol) hydrogel crosslinking mechanism on protein release, Biomater. Sci., 2016, 4, 405-411. [PMID 26539660] [PMC5127629]
  21. Lee, S.; Tong, X.; Han, L.; Behn, A.; Yang, F., Aligned Microribbon-like Hydrogels for Guiding Three-dimensional Smooth Muscle Tissue Regeneration,J. Biomed. Mater. Res. Part A, 2016, 104, 1064-1071.[PMID 26799256] [PMC5127626]
  22. Deveza, L.; Ashoken, J.; Castaneda, G.; Tong, X.; Keeney, M.; Han L.H.; Yang, F., Microfluidic Synthesis of Biodegradable Polyethylene-Glycol Microspheres for Controlled Delivery of Proteins and DNA Nanoparticles, ACS Biomater. Sci. Eng., 2015, 1, 157-165. [view]
  23. Nejadnik, H.; Diecke, S.; Lenkov, O.D.; Chapelin, F.; Doing, J.; Fathi, A.; Tong, X.; Derugin, N.; Chan, R.C.; Gaur, A.; Yang, F.; Wu, J.C.; Daldrup-Link, H.E., Improved approach for chondrogenic differentiation of human induced pluripotent stem cells, Stem Cell Rev., 2015, 11, 242-253. [PMID 25578634] [PMC4412587]
  24. Lee, S.; Tong, X.; Yang, F., The effects of varying poly(ethylene glycol) hydrogel crosslinking density and crosslinking mechanism on protein accumulation in three-dimensional hydrogels, Acta Biomater., 2014, 10, 4167-4174.[PMID 24887284]
  25. Wang, C.; Tong, X.; Yang, F., Bioengineered 3D brain tumor model to elucidate the effects of matrix stiffness on glioblastoma cell behavior using PEG-based hydrogels, Mol. Pharm., 2014, 11, 2115-2125.[PMID 24712441]
  26. Wang, T.Y.; Lai, J.H.; Han, L.H.; Tong, X.; Yang, F., Chondrogenic differentiation of adipose-derived stromal cells in combinatorial hydrogels containing cartilage matrix proteins with decoupled mechanical stiffnesses, Tissue Eng. Part A., 2014, 20, 2131-2139. [PMID 24707837]
  27. Han, L.H.; Tong, X.; Yang, F., Photocrosslinkable PEG-based microribbons for forming 3D macroporous scaffolds with decoupled niche properties, Adv. Mater., 2014, 26, 1757-62.[PMID 24347028]
  28. Keeney, M.; Onyiah, S.; Zhang, Z.; Tong, X.; Han, L.H.; Yang, F., Modulating polymer chemistry to enhance non-viral gene delivery inside hydrogels with tunable matrix stiffness, Biomaterials, 2013, 34, 9657-9665.[PMID 24011715]
  29. Hammer, J.; Han, L.H.; Tong, X.; Yang, F., A Cell-friendly Process to Fabricate Hydrogels with Microchannel-like Porosity for Tissue Engineering, Tissue Eng., 2013, 20, 169-176.[PMID 23745610]
  30. Keeney, M.; Mathur, M.; Cheng, E.; Tong, X.; Yang, F., The effects of polymer end-group chemistry and order of deposition on controlled protein delivery from layer-by-layer assembly. Biomacromolecules, 2013, 14, 794-800.[view]
  31. Tao, Y.; Tong, X.; Zhang, Y.; Lai, J.; Huang, Y.; Jiang, Y.-R.; Guo, B.-H., Evaluation of an in situ chemically crosslinked hydrogel as a long-term vitreous substitute material. Acta Biomater., 2013, 9, 5022-30.[PMID 23022890]
  32. Zhang, X.; Zhu, X.; Tong, X.; Ye, L.; Zhang, A.; Feng, Z., Novel main-chain polyrotaxanes synthesized via ATRP of HPMA in aqueous media. J. Polym. Sci., Part A: Polym. Chem., 2008, 46, 5283-5293.[view]
  33. Hou, D.; *Tong, X.*; Yu, H.; Zhang, A.; Feng, Z., A kind of novel biodegradable hydrogel made from copolymerization of gelatin with polypseudorotaxanes based on alpha-CDs. Biomed. Mater., 2007, 2, S147-S152.[PMID 18458460]

Peer-reviewed papers | Patents | Conference abstracts

  1. Han, L.; Yang, F.; Tong, X. “Macroporous 3-D scaffolds for tissue engineering”. (US Patent 9,402,710 B2, 2016.)
  2. Yang, F.; Han, L.; Tong X. “Dynamic macropore formation using multiple porogens”. (US Patent 9,415,138 B2, 2016)
  3. Tao, Y.; Jiang, Y.; Guo, B.; Huang, Y.; Tong, X. “Application of in-situ crosslinking hydrogel capable of intraocular injection in preparing artificial vitreous bodies”. (Chinese Patent CN 101934089, 2013)
  4. Tong, X.; Guo, B.; Lai, J.; Huang, Y., “Polymer capable of performing addition reaction with thiol and having stable bonding hydrolysis”. (‘Chinese Patent CN 101885841, 2012.)

Peer-reviewed papers | Patents | Conference abstracts

  1. Tong, X.; Yang, F., “Macroprous extracellular matrix-based microribbon hydrogels enhance osteogenesis of mesenchymal stem cells in 3D”, Poster presentation at 2017 ORS annual meeting, San Diego, CA, 2017.
  2. Tong, X.; Qiu, K.; Yang, F., “Elucidating interplay of physical and biochemical cues on osteogenesis of mesenchymal stem cells in 3D using biomimetic hydrogels”, Poster presentation at 2017 ORS annual meeting, San Diego, CA, 2017.
  3. Tong, X.; Yang, F., “Sliding hydrogels with mobile molecular ligands and crosslinks enhance differentiation of human mesenchymal stem cells toward multiple lineages”, Oral presentation at 2016 TERMIS-AM annual conference, San Diego, CA, 2016.
  4. Tong, X.; Yang, F., “Fabricating extracellular-matrix derived microribbon-like hydrogels to modulate osteogenesis of human mesenchymal stem cells”, Poster presentation at 2016 TERMIS-AM annual conference, San Diego, CA, 2016.
  5. Tong, X.; Yang, F., “Engineering Sliding Hydrogels with Molecular Mobility as 3D Stem Cell Niche”, Oral presentation at 2015 Biomedical Engineering Society Annual Meeting, Tampa, FL, 2015.
  6. Tong, X.; Gegg, C.; Yang, F., “Engineering Microribbon-Like Hydrogels with Diverse Biological Cues to Form 3D Scaffolds as Stem Cell Niche”, Poster presentation at 2015 Society For Biomaterials Annual Meeting, Charlotte, NC, 2015.
  7. Tong, X.; Yang, F., “Engineering 3D sliding hydrogels with mobile molecular ligands to direct stem cell differentiation”, Oral presentation at 2015 Society For Biomaterials Annual Meeting, Charlotte, NC, 2015.
  8. Tong, X.; Jiang, J.; Zhu, D.; Yang, F., “Engineering Hydrogels with Dual Gradients of Mechanical and Biochemical Cues to Decipher Stem Cell-Niche Interactions”, Poster presentation at 2015 Society For Biomaterials Annual Meeting, Charlotte, NC, 2015.
  9. Tong, X.; Lee, S.; Wen, Y.; Phadnis, S.; Chen, B.; Reijo P.R.; Yang, F., “Injectable hydrogels as cell delivery matrices for smooth muscle repair”, Oral presentation at 2014 Material Research Society Annual Spring Meeting, San Francisco, CA, 2014.
  10. Tong, X.; Yang, F., “Engineering interpenetrating network hydrogels as biomimetic cell niche with independently tunable biochemical and mechanical properties”, Poster presentation at 2014 Society For Biomaterials Annual Meeting, Denver, CO, 2014.
  11. Tong, X.; Jiang, J.; Zhu, D.; Yang, F., “Engineering Hydrogels with Dual Gradients of Mechanical and Biochemical Cues to Decipher Stem Cell-Niche Interactions”, Poster presentation at 2014 Society For Biomaterials Annual Meeting, Denver, CO, 2014.
  12. Huang, Y.; Tong, X.; Yang, D.; Lai J., “Is it possible to achieve monomer-level sequence control in vinyl copolymers?”, Oral presentation at 246st National Meeting and Exposition of the American Chemical Society, Indianapolis, IN, 2013.
  13. Tong, X.; Yang, F. “Biomimetic Interpenetrating Network for Controlling Osteogenesis of Stem Cell in 3D Combinatorial Hydrogels”, Poster presentation at 2013 Material Research Society Annual Spring Meeting, San Francisco, CA, 2013.
  14. Tong, X.; Lee, S.; Bararpour, L.; Yang, F. “Long-Term Sustained Protein Release from Hydrogels by Tuning Poly(Ethylene Glycol) Structure and Degradation”, Poster presentation at 2013 Material Research Society Annual Spring Meeting, San Francisco, CA, 2013.
  15. Tong, X.; Yang, F. “Engineering Stem Cell Microenvironment with independently tunable biochemical and mechanical properties”, Oral presentation at 2012 Material Research Society Annual Spring Meeting, San Francisco, CA, 2012.
  16. Tong, X.; Lai, J.; Guo, B.-H.; Huang, Y.; Tao, Y.; Jiang, Y.-R.; Zhang, Y.; Wang, X.-L., “PEG based hydrolysis-resistant in situ hydrogel for vitreous substitutes”, Poster presentation at 241st National Meeting and Exposition of the American Chemical Society, Anaheim, CA, 2011.